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Article

Oncogenic potential of IDH1R132C mutant in cholangiocarcinoma development in mice.

World journal of gastroenterology - 14 Feb 2016

Ding Ning, Che Li, Li Xiao-Lei, Liu Yan, Jiang Li-Jie, Fan Biao, Tao Jun-Yan, Chen Xin, Ji Jia-Fu

Abstract excerpt

AIM: To investigate whether IDH1R132C mutant in combination with loss of p53 and activated Notch signaling promotes intrahepatic cholangiocarcinoma (ICC) development. METHODS: We applied hydrodynamic injection and sleeping beauty mediated somatic integration to induce loss of p53 (via shP53), activation of Notch [via intracellular domain of Notch1 (NICD)] and/or overexpression of IDH1R132C mutant together with...

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Share to Bile Duct Neoplasms
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Enzymologic

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Share to Receptors, Notch

Source

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Identifiers

PMID: 26877611
DOI: 10.3748/wjg.v22.i6.2071
PMCID: PMC4726679

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