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Article

Functional genetic polymorphisms in PP2A subunit genes confer increased risks of lung cancer in southern and eastern Chinese.

PloS one - 1 Jan 2013

Yang Rongrong, Yang Lei, Qiu Fuman, Zhang Lisha, Wang Hui, Yang Xiaorong, Deng Jieqiong, Fang Wenxiang, Zhou Yifeng, Lu Jiachun

Abstract excerpt

Protein phosphatase-2A (PP2A) is one of the major cellular serine-threonine phosphatases and functions as a tumor suppressor that negatively regulates the activity of some oncogenic kinases. Recent studies have reported that PP2A expression was suppressed during lung carcinogenesis, we there hypothesized that the single nucleotide polymorphisms (SNPs) in PP2A subunit genes may affect PP2A function and thus...

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Identifiers

PMID: 24204789
DOI: 10.1371/journal.pone.0077285
PMCID: PMC3812212

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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