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Article

A functional polymorphism in the 3'-UTR of PXR interacts with smoking to increase lung cancer risk in southern and eastern Chinese smoker.

International journal of molecular sciences - 29 Sept 2014

Zhang Lisha, Qiu Fuman, Lu Xiaoxiao, Li Yinyan, Fang Wenxiang, Zhang Lan, Zhou Yifeng, Yang Lei, Lu Jiachun

Abstract excerpt

Pregnane X receptor (PXR) is an important member of the nuclear receptor superfamily that copes with various endobiotic and xenobiotic stimuli, such as carcinogens by regulating an array of environmental response genes. Low PXR expression has been shown to promote tumor initiation and metastasis. The aim of the current study was to investigate whether the single nucleotide polymorphisms (SNPs) of PXR could alter...

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Identifiers

PMID: 25268617
DOI: 10.3390/ijms151017457
PMCID: PMC4227172

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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