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Article

The polymorphism and haplotypes of PIN1 gene are associated with the risk of lung cancer in Southern and Eastern Chinese populations.

Human mutation - 1 Nov 2011

Lu Jiachun, Yang Lei, Zhao Hongjun, Liu Bin, Li Yinyan, Wu Hongxia, Li Qingchu, Zeng Bohang, Wang Yunnan, Ji Weidong, Zhou Yifeng

Abstract excerpt

Peptidyl-prolyl cis/trans isomerase (PPIase), PIN1, has been found to be a critical catalyst that involves in multiple oncogenic signaling pathways. Recently, several putative functional polymorphisms of the PIN1 gene have been identified to be associated with cancer risk. In this study, we tested the hypothesis that two common polymorphisms, c.-842G>C (rs2233678) and c.-667C>T (rs2233679), in the PIN1 promoter...

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Source

Identifiers

PMID: 21850685
DOI: 10.1002/humu.21574

Genes

PIN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Click a neighbor to travelStep 1 · 12 closest

The polymorphism and haplotypes of PIN1 gene are associated with the risk of lung cancer in Southern and Eastern Chinese populations.PMID 21850685Read ↗

Pin1 promoter rs2233678 and rs2233679 polymorphisms in cancer: a meta-analysis.Semantic proximity Read ↗

Functional polymorphisms in PIN1 promoter and esophageal carcinoma susceptibility in Chinese population.Semantic proximity Read ↗

The Pin1 gene polymorphism and the susceptibility of oral squamous cell carcinoma in East China.Semantic proximity Read ↗

Association of rs2233678 and rs2233679 polymorphisms in the PIN1 gene with cancer risk: a meta-analysis.Semantic proximity Read ↗

The -842G/C polymorphisms of PIN1 contributes to cancer risk: a meta-analysis of 10 case-control studies.Semantic proximity Read ↗

A novel functional variant (-842G>C) in the PIN1 promoter contributes to decreased risk of squamous cell carcinoma of the head and neck by diminishing the promoter activity.Semantic proximity Read ↗

Association between PIN1 promoter polymorphisms and risk of nasopharyngeal carcinoma.Semantic proximity Read ↗

Single nucleotide polymorphisms of PIN1 promoter region and cancer risk: evidence from a meta-analysis.Semantic proximity Read ↗

Functional PIN1 promoter polymorphisms associated with risk of nasopharyngeal carcinoma in Southern Chinese populations.Semantic proximity Read ↗

The rs2233678 polymorphism in PIN1 promoter region reduced cancer risk: a meta-analysis.Semantic proximity Read ↗

Functional polymorphism of PIN1 rs2233679 is associated with the progression of CIN to early cervical cancer in Hunan Chinese.Semantic proximity Read ↗

The functional promoter polymorphism (-842G>C) in the PIN1 gene is associated with decreased risk of breast cancer in non-Hispanic white women 55 years and younger.Semantic proximity Read ↗

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