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Article

Potentially functional variants of PLCE1 identified by GWASs contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population.

PloS one - 1 Jan 2012

Wang Mengyun, Zhang Ruoxin, He Jing, Qiu Lixin, Li Jin, Wang Yanong, Sun Menghong, Yang Yajun, Wang Jiucun, Yang Jingmin, Qian Ji, Jin Li, Ma Hongxia, Wei Qingyi, Zhou Xiaoyan

Abstract excerpt

BACKGROUND: Recent genome-wide association studies (GWAS) have found a single nucleotide polymorphism (SNP, rs2274223 A>G) in PLCE1 to be associated with risk of gastric adenocarcinoma. In the present study, we validated this finding and also explored the risk associated with another unreported potentially functional SNP (rs11187870 G>C) of PLCE1 in a hospital-based case-control study of 1059 patients with...

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Identifiers

PMID: 22412849
DOI: 10.1371/journal.pone.0031932
PMCID: PMC3295761

Genes

PLCE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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