Article
Role of a novel functional variant in the PPP2R1A promoter on the regulation of PP2A-Aalpha and the risk of hepatocellular carcinoma.
PloS one - 1 Jan 2013
Chen Hui-Feng, Mai Jian-Rong, Wan Jian-Xin, Gao Yan-fang, Lin Li-Na, Wang Song-Zi, Chen Yu-Xi, Zhang Chen-Zi, Zhang Yu-Jing, Xia Bin, Liao Kun, Lin Yu-Chun, Lin Zhong-Ning
Abstract excerpt
Previously, we identified the genetic variant -241 (-/G) (rs11453459) in the PP2A-Aα gene (PPP2R1A) promoter and demonstrated that this variant influences the DNA-binding affinity of nuclear factor-kappa B (NF-κB). In this study, we further confirmed that the transcriptional activity of PPP2R1A may be regulated by NF-κB through the functional genetic variant -241 (-/G). Moreover, we also demonstrated that the...
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