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Article

Lrp6 Dynamic Expression in Tooth Development and Mutations in Oligodontia.

Journal of dental research - 1 Apr 2021

Yu M, Fan Z, Wong S W, Sun K, Zhang L, Liu H, Feng H, Liu Y, Han D

Abstract excerpt

Genes associated with the WNT pathway play an important role in the etiology of tooth agenesis. Low-density lipoprotein receptor-related protein 6 encoding gene (LRP6) is a recently defined gene that is associated with autosomal dominant inherited tooth agenesis. Here, we aimed to identify novel LRP6 mutations in patients with tooth agenesis and investigate the significance of Lrp6 during tooth development. Using...

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PMID: 33164649
DOI: 10.1177/0022034520970459

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