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Article

Acceleration of biliary cholesterol secretion restores glycemic control and alleviates hypertriglyceridemia in obese db/db mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2014

Su Kai, Sabeva Nadezhda S, Wang Yuhuan, Liu Xiaoxi, Lester Joshua D, Liu Jingjing, Liang Shuang, Graf Gregory A

Abstract excerpt

OBJECTIVE: Recent studies support a role for cholesterol in the development of obesity and nonalcoholic fatty liver disease. Mice lacking the ABCG5 ABCG8 (G5G8) sterol transporter have reduced biliary cholesterol secretion and are more susceptible to steatosis, hepatic insulin resistance, and los...

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Source

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Identifiers

PMID: 24202306
DOI: 10.1161/ATVBAHA.113.302355
PMCID: PMC4096285

Genes

ABCG5
ABCG8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24202306-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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