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Article

Hepatic ABCG5/G8 overexpression substantially increases biliary cholesterol secretion but does not impact in vivo macrophage-to-feces RCT.

Atherosclerosis - 1 Dec 2015

Dikkers Arne, de Boer Jan Freark, Groen Albert K, Tietge Uwe J F

Abstract excerpt

BACKGROUND AND AIMS: Biliary cholesterol secretion is important for reverse cholesterol transport (RCT). ABCG5/G8 contribute most cholesterol mass secretion into bile. We investigated the impact of hepatic ABCG5/G8 on cholesterol metabolism and RCT. METHODS: Biliary and fecal sterol excretion (FSE) as well as RCT were determined using wild-type controls, Abcg8 knockout mice, Abcg8 knockouts with...

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PMID: 26520893
DOI: 10.1016/j.atherosclerosis.2015.10.010

Genes

ABCG5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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