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Article

Irritable bowel syndrome-diarrhea: characterization of genotype by exome sequencing, and phenotypes of bile acid synthesis and colonic transit.

American journal of physiology. Gastrointestinal and liver physiology - 1 Jan 2014

Camilleri Michael, Klee Eric W, Shin Andrea, Carlson Paula, Li Ying, Grover Madhusudan, Zinsmeister Alan R

Abstract excerpt

The study objectives were: to mine the complete exome to identify putative rare single nucleotide variants (SNVs) associated with irritable bowel syndrome (IBS)-diarrhea (IBS-D) phenotype, to assess genes that regulate bile acids in IBS-D, and to explore univariate associations of SNVs with symptom phenotype and quantitative traits in an independent IBS cohort. Using principal components analysis, we identified...

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Share to Bile Acids and Salts
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Klotho Proteins

Share to Receptor, Fibroblast Growth Factor, Type 4

Source

Open in PubMed Open full text

Identifiers

PMID: 24200957
DOI: 10.1152/ajpgi.00294.2013
PMCID: PMC3920085

Genes

FGFR4
KLB
FGF19
FABP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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