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Article

Genetic dissection of stool frequency implicates vitamin B1 metabolism and other actionable pathways in the modulation of gut motility.

Gut - 8 Jul 2026

Díaz-Muñoz Cristian, Bozzarelli Isotta, Lopera-Maya Esteban Alexander, Belbasis Lazaros, Lo Faro Valeria, Camargo Tavares Leticia, Heredia-Fernández Francisco, Di Lorenzo Biagio, Sinha Trishla, Esteban Blanco Cristina, Favé Marie-Julie, Awadalla Philip, Walters Robin G, Bonfiglio Ferdinando, Zhernakova Alexandra, Sanna Serena, D'Amato Mauro

Abstract excerpt

BACKGROUND: Genetic studies of stool frequency (SF), an indirect proxy for gastrointestinal transit, may reveal therapeutically tractable pathways relevant to IBS and other dysmotility disorders. OBJECTIVE: To identify genes and mechanisms involved in gut motility, providing a foundation for clinical translation. DESIGN: We performed a multiancestry genome-wide association study (GWAS) meta-analysis of SF in...

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East Asian People
European People
Gastrointestinal Motility
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Irritable Bowel Syndrome

Polymorphism, Single Nucleotide

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Open in PubMed Open full text

Identifiers

PMID: 41558814
DOI: 10.1136/gutjnl-2025-337059
PMCID: PMC13479210

Genes

SLC35F3
XPR1
COLQ
KLB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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