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Article

A Klothoβ variant mediates protein stability and associates with colon transit in irritable bowel syndrome with diarrhea.

Gastroenterology - 1 Jun 2011

Wong Banny S, Camilleri Michael, Carlson Paula J, Guicciardi Maria E, Burton Duane, McKinzie Sanna, Rao Archana S, Zinsmeister Alan R, Gores Gregory J

Abstract excerpt

BACKGROUND & AIMS: Bile acid (BA) malabsorption of moderate severity is reported in 32% of patients with chronic unexplained diarrhea, including diarrhea-predominant irritable bowel syndrome (IBS-D). We hypothesized that variants of genes regulating hepatic BA synthesis play a role in IBS-D. METHODS: In 435 IBS and 279 healthy subjects, we tested individual associations of 15 common single nucleotide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21396369
DOI: 10.1053/j.gastro.2011.02.063
PMCID: PMC3109206

Genes

KLB
FGFR4
FGF19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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