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Article

Genetic variation in GPBAR1 predisposes to quantitative changes in colonic transit and bile acid excretion.

American journal of physiology. Gastrointestinal and liver physiology - 1 Sept 2014

Camilleri Michael, Shin Andrea, Busciglio Irene, Carlson Paula, Acosta Andres, Bharucha Adil E, Burton Duane, Lamsam Jesse, Lueke Alan, Donato Leslie J, Zinsmeister Alan R

Abstract excerpt

The pathobiology of irritable bowel syndrome (IBS) is multifaceted. We aimed to identify candidate genes predisposing to quantitative traits in IBS. In 30 healthy volunteers, 30 IBS-constipation, and 64 IBS-diarrhea patients, we measured bowel symptoms, bile acid (BA) synthesis (serum 7α-hydroxy-4-cholesten-3-one and FGF19), fecal BA and fat, colonic transit (CT by scintigraphy), and intestinal permeability (IP...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25012842
DOI: 10.1152/ajpgi.00178.2014
PMCID: PMC4154122

Genes

GPBAR1
KLB
SLC6A4
FGF19
FGFR4
TNFSF15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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