Article

Multi-ancestry GWAS of diarrhea during acute SARS-CoV2 infection identifies multiple novel loci and contrasting etiological roles of irritable bowel syndrome subtypes

2024-04-04

Abstract excerpt

<h4>ABSTRACT</h4> A substantial proportion of acute SARS-CoV2 infection cases exhibit gastrointestinal symptoms, yet the genetic determinants of these extrapulmonary manifestations are poorly understood. Using survey data from 239,866 individuals who tested positively for SARS-CoV2, we conducted a multi-ancestry GWAS of 80,289 cases of diarrhea occurring during acute COVID-19 infection (33.5%). Six loci ( CYP7A1,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7398485a-0a31-52d2-b868-74e0f9d0490a
DOI: 10.1101/2024.04.03.24305274

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multi-ancestry GWAS of diarrhea during acute SARS-CoV2 infection identifies multiple novel loci and contrasting etiological roles of irritable bowel syndrome subtypesDOI 10.1101/2024.04.03.24305274Read

Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics Initiative.Semantic proximity Read

Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics InitiativeSemantic proximity Read

Genome-wide association studies of COVID-19: Connecting the dotsSemantic proximity Read

Shared genetic architecture between COVID-19 and irritable bowel syndrome: a large-scale genome-wide cross-trait analysis.Semantic proximity Read

Systematic assessment of COVID-19 host genetics using whole genome sequencing data.Semantic proximity Read

AncestryDNA COVID-19 Host Genetic Study Identifies Three Novel LociSemantic proximity Read

COVID-19 relevant genetic variants confirmed in an admixed populationSemantic proximity Read

Irritable bowel syndrome-diarrhea: characterization of genotype by exome sequencing, and phenotypes of bile acid synthesis and colonic transit.Semantic proximity Read

Integrative Genome-Wide Association Studies of COVID-19 Susceptibility and Hospitalization Reveal Risk Loci for Long COVIDSemantic proximity Read

Trans-ancestry analysis reveals genetic and nongenetic associations with COVID-19 susceptibility and severity.Semantic proximity Read

A year of Covid-19 GWAS results from the GRASP portal reveals potential SARS-CoV-2 modifiersSemantic proximity Read

Host genetic loci LZTFL1 and CCL2 associated with SARS-CoV-2 infection and severity of COVID-19Semantic proximity Read