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Article

Association of bile acid receptor TGR5 variation and transit in health and lower functional gastrointestinal disorders.

Neurogastroenterology and motility - 1 Nov 2011

Camilleri M, Vazquez-Roque M I, Carlson P, Burton D, Wong B S, Zinsmeister A R

Abstract excerpt

BACKGROUND: The membrane bound bile acid (BA) receptor, TGR5, is located on myenteric, cholinergic and nitrergic neurons in colon and proximal small intestine. Our aim was to assess the association of genetic variation in TGR5 and small bowel transit (SBT) and colonic transit. METHODS: In 230 healthy controls and 414 patients with lower functional GI disorders [FGID: irritable bowel syndrome (IBS)-alternators...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21883702
DOI: 10.1111/j.1365-2982.2011.01772.x
PMCID: PMC3190664

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