Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Stochastic modelling of genotypic drug-resistance for human immunodeficiency virus towards long-term combination therapy optimization.

Bioinformatics (Oxford, England) - 15 Apr 2009

Prosperi Mattia C F, D'Autilia Roberto, Incardona Francesca, De Luca Andrea, Zazzi Maurizio, Ulivi Giovanni

Abstract excerpt

MOTIVATION: Several mathematical models have been investigated for the description of viral dynamics in the human body: HIV-1 infection is a particular and interesting scenario, because the virus attacks cells of the immune system that have a role in the antibody production and its high mutation rate permits to escape both the immune response and, in some cases, the drug pressure. The viral genetic evolution is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Resistance, Viral
Share to Drug Therapy, Combination

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genotype

Share to HIV/AIDS drug development and treatment

Share to HIV Infections

Share to HIV Research and Treatment

Share to Models, Biological

Source

Identifiers

PMID: 18977781
DOI: 10.1093/bioinformatics/btn568

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Stochastic modelling of genotypic drug-resistance for human immunodeficiency virus towards long-term combination therapy optimization.PMID 18977781Read ↗

Mathematical approaches in the study of viral kinetics and drug resistance in HIV-1 infection.Semantic proximity Read ↗

Resistance to protease inhibitors in a model of HIV-1 infection with impulsive drug effects.Semantic proximity Read ↗

Use of a stochastic model to develop understanding of the impact of different patterns of antiretroviral drug use on resistance development.Semantic proximity Read ↗

A Darwinian model for the evolution of drug resistance to long-acting PrEP during an early HIV infection.Semantic proximity Read ↗

Machine learning aided multiscale modelling of the HIV-1 infection in the presence of NRTI therapySemantic proximity Read ↗

An evaluation of the emergence of drug resistant virus for HIV/AIDS drug treatments.Semantic proximity Read ↗

A stochastic model for primary HIV infection: optimal timing of therapy.Semantic proximity Read ↗

Kinetic co-evolutionary models predict the temporal emergence of HIV resistance mutations under drug selection pressureSemantic proximity Read ↗

Stochastic modeling of drug resistance in cancer.Semantic proximity Read ↗

Development of a stochastic model for the efficacy of NRTIs using known mechanisms of action.Semantic proximity Read ↗

A Mathematical Model of Combined Drug Therapy of HIV InfectionSemantic proximity Read ↗

Mathematical analysis of a class of HIV infection models of CD4+ T-cells with combined antiretroviral therapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.