A high frequency of activating extracellular domain ERBB2 (HER2) mutation in micropapillary urothelial carcinoma.

doi:10.1158/1078-0432.CCR-13-1992

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Article

A high frequency of activating extracellular domain ERBB2 (HER2) mutation in micropapillary urothelial carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2014

Ross Jeffrey S, Wang Kai, Gay Laurie M, Al-Rohil Rami N, Nazeer Tipu, Sheehan Christine E, Jennings Timothy A, Otto Geoff A, Donahue Amy, He Jie, Palmer Gary, Ali Siraj, Nahas Michelle, Young Geneva, Labrecque Elaine, Frampton Garrett, Erlich Rachel, Curran John A, Brennan Kristina, Downing Sean R, Yelensky Roman, Lipson Doron, Hawryluk Matthew, Miller Vincent A, Stephens Philip J

Abstract excerpt

PURPOSE: Micropapillary urothelial carcinoma (MPUC) is a rare and aggressive form of bladder cancer. We conducted genomic analyses [next-generation sequencing (NGS)] of MPUC and non-micropapillary urothelial bladder carcinomas (non-MPUC) to characterize the genomic landscape and identify targeted treatment options. EXPERIMENTAL DESIGN: DNA was extracted from 40 μm of formalin-fixed paraffin-embedded sections from...

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PMID: 24192927
DOI: 10.1158/1078-0432.CCR-13-1992

Genes

ERBB2

Variants

Provenance

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