Article
Molecular Landscape of ERBB2 Alterations in 14,956 Solid Tumors.
Pathology oncology research : POR - 1 Jan 2022
Wang Hao, Miao Ji, Wen Yazhou, Xia Xihua, Chen Yanan, Huang Mengli, Chen Shiqing, Zhao Zhengyi, Zhang Yuzi, Chen Chunzhu, Zhu Xinhua
Abstract excerpt
ERBB2 abnormalities frequently occur and serve as rationale therapeutic targets in cancer. In this study, clinical and next-generation sequencing data from 14,956 patients across more than 20 tumor types were collected. A total of 406 (2.7%) patients were identified with ERBB2 amplifications, and 303 (2.0%) patients with pathogenic somatic ERBB2 mutations. ERBB2 amplifications fell most frequently in breast...
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