Characterizing the Genomic Landscape of the Micropapillary Subtype of Urothelial Carcinoma of the Bladder Harboring Activating Extracellular Mutations of ERBB2.

doi:10.1016/j.modpat.2024.100424

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Article

Characterizing the Genomic Landscape of the Micropapillary Subtype of Urothelial Carcinoma of the Bladder Harboring Activating Extracellular Mutations of ERBB2.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Mar 2024

Posada Jessica M, Yakirevich Evgeny, Kamat Ashish M, Sood Akshay, Jacob Joseph M, Bratslavsky Gennady, Grivas Petros, Spiess Philippe E, Li Roger, Necchi Andrea, Mega Anthony E, Golijanin Dragan J, Pavlick Dean, Huang Richard S P, Lin Douglas, Danziger Natalie, Sokol Ethan S, Sivakumar Smruthy, Ross Jeffrey S, Cheng Liang

Abstract excerpt

The micropapillary subtype of urothelial carcinoma (MPUC) of the bladder is a very aggressive histological variant of urothelial bladder cancer (UBC). A high frequency of MPUC contains activating mutations in the extracellular domain (ECD) of ERBB2. We sought to further characterize ERBB2 ECD-mutated MPUC to identify additional genomic alterations that have been associated with tumor progression and therapeutic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38219954
DOI: 10.1016/j.modpat.2024.100424

Genes

ERBB2
ECD
UBC
KMT2D
RB1
MTAP
ARID1A
TERT
TP53

Variants

Provenance

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