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Frequency and Nature of Genomic Alterations in ERBB2-Altered Urothelial Bladder Cancer.

Targeted oncology - 1 May 2024

Leary Jacob B, Enright Thomas, Bakaloudi Dimitra Rafailia, Basnet Alina, Bratslavsky Gennady, Jacob Joseph, Spiess Philippe E, Li Roger, Necchi Andrea, Kamat Ashish M, Pavlick Dean C, Danziger Natalie, Huang Richard S P, Lin Douglas I, Cheng Liang, Ross Jeffrey, Talukder Rafee, Grivas Petros

Abstract excerpt

BACKGROUND: Human epidermal growth factor-2 (HER2) overexpression is an oncogenic driver in many solid tumors, including urothelial bladder cancer (UBC). In addition, activating mutations in the ERBB2 gene have been shown to play an oncogenic role similar to ERBB2 amplification. OBJECTIVE: To describe and compare the frequency and nature of genomic alterations (GA) of ERBB2-altered (mutations, amplification) and...

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Genomics
Mutation
Receptor, ErbB-2

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Urinary Bladder Neoplasms

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PMID: 38570422
DOI: 10.1007/s11523-024-01056-x

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