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Article

Dominant-negative activity of the STAT3-Y705F mutant depends on the N-terminal domain.

Cell communication and signaling : CCS - 5 Nov 2013

Mohr Anne, Fahrenkamp Dirk, Rinis Natalie, Müller-Newen Gerhard

Abstract excerpt

BACKGROUND: STAT3 is a transcription factor of central importance in chronic inflammation and cancer. In response to cytokine stimulation STAT3 is phosphorylated on a single tyrosine residue at position 705, dimerizes and accumulates in the nucleus to induce target gene expression. The substitution of tyrosine 705 to phenylalanine leads to a dominant-negative STAT3 mutant (STAT3-YF) which influences the...

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Share to Cytokine Receptor gp130

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24192293
DOI: 10.1186/1478-811X-11-83
PMCID: PMC3833267

Genes

STAT3
CFP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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