Article
Activation of STAT6 is not dependent on phosphotyrosine-mediated docking to the interleukin-4 receptor and can be blocked by dominant-negative mutants of both receptor subunits.
European journal of biochemistry - 15 Jan 1998
Moriggl R, Erhardt I, Kammer W, Berchtold S, Schnarr B, Lischke A, Groner B, Friedrich K
Abstract excerpt
Stimulation of susceptible cells by interleukin-4 leads to activation of signal transducer and activator of transcription (STAT6) through tyrosine phosphorylation and dimerisation, thus directing it to the cell nucleus and rendering it a sequence-specific transcription factor. We functionally rec...
Topics
- Animals
- COS Cells
- Cytoplasm
- Genes, Dominant
- Humans
- Interleukin-13
- Interleukin-4
- Janus Kinase 1
- Mice
- Mutation
- Phosphorylation
- Phosphotyrosine
- Protein-Tyrosine Kinases
- Receptors, Interleukin-4
- Recombinant Proteins