Article
Real time analysis of STAT3 nucleocytoplasmic shuttling.
The Journal of biological chemistry - 9 Apr 2004
Pranada Albert L, Metz Silke, Herrmann Andreas, Heinrich Peter C, Müller-Newen Gerhard
Abstract excerpt
The transcription factor STAT3 is most important for the signal transduction of interleukin-6 and related cytokines. Upon stimulation cytoplasmic STAT3 is phosphorylated at tyrosine 705, translocates into the nucleus, and induces target genes. Notably, STAT proteins are also detectable in the nuclei of unstimulated cells. In this report we introduce a new method for the real time analysis of STAT3...
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