Article
The STAT3 isoforms alpha and beta have unique and specific functions.
Nature immunology - 1 Apr 2004
Maritano Diego, Sugrue Michelle L, Tininini Silvia, Dewilde Sarah, Strobl Birgit, Fu XinPing, Murray-Tait Victoria, Chiarle Roberto, Poli Valeria
Abstract excerpt
Signal transducer and activator of transcription 3 (STAT3) is the main mediator of interleukin 6 (IL-6)-type cytokine signaling. It exists in two isoforms: the full-length STAT3 alpha and the truncated STAT3 beta, generally thought to act as a dominant negative factor. To assess their relative functions, we ablated the expression of either isoform by gene targeting. We show here that in vivo STAT3 beta is not a...
Topics
- Animals
- DNA-Binding Proteins
- Fertility
- Genes, Lethal
- Immunoblotting
- Inflammation
- Interleukin-6
- Kidney
- Liver
- Lung
- Mice
- Mutation