Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A reactive oxygen species-mediated, self-perpetuating loop persistently activates platelet-derived growth factor receptor α.

Molecular and cellular biology - 1 Jan 2014

Lei Hetian, Kazlauskas Andrius

Abstract excerpt

The platelet-derived growth factor (PDGF) receptors (PDGFRs) are central to a spectrum of human diseases. When PDGFRs are activated by PDGF, reactive oxygen species (ROS) and Src family kinases (SFKs) act downstream of PDGFRs to enhance PDGF-mediated tyrosine phosphorylation of various signaling intermediates. In contrast to these firmly established principles of signal transduction, much less is known regarding...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy
Share to Intercellular Signaling Peptides and Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microscopy, Confocal

Share to Rabbits

Share to Receptor, Platelet-Derived Growth Factor alpha

Share to src-Family Kinases

Share to TOR Serine-Threonine Kinases

Share to Vitreous Body

Source

Open in PubMed Open full text

Identifiers

PMID: 24190966
DOI: 10.1128/MCB.00839-13
PMCID: PMC3911282

Genes

PVR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A reactive oxygen species-mediated, self-perpetuating loop persistently activates platelet-derived growth factor receptor α.PMID 24190966Read ↗

Ligand-independent Activation of Platelet-derived Growth Factor Receptor β promotes contraction of retinal pigment epithelial cellsSemantic proximity Read ↗

Roles of PDGF/PDGFR signaling in various organsSemantic proximity Read ↗

Vascular Endothelial Growth Factor A Competitively Inhibits Platelet-Derived Growth Factor (PDGF)-Dependent Activation of PDGF Receptor and Subsequent Signaling Events and Cellular ResponsesSemantic proximity Read ↗

The Novel Pathogenesis of Retinopathy Mediated by Multiple RTK Signals is Uncovered in Newly Developed Mouse ModelSemantic proximity Read ↗

Role of platelet-derived growth factors in physiology and medicine.Semantic proximity Read ↗

Detection of H2O2-mediated phosphorylation of kinase-inactive PDGFRα.Semantic proximity Read ↗

Platelet-derived growth factor and reactive oxygen species (ROS) regulate Ras protein levels in primary human fibroblasts via ERK1/2. Amplification of ROS and Ras in systemic sclerosis fibroblasts.Semantic proximity Read ↗

Pathogenetic significance and possibility as a therapeutic target of platelet derived growth factorSemantic proximity Read ↗

PDGF receptor signaling networks in normal and cancer cellsSemantic proximity Read ↗

Plastic roles of pericytes in the blood–retinal barrierSemantic proximity Read ↗

Platelet-derived Growth Factor Signaling and Human CancerSemantic proximity Read ↗

PDGF-A Strengthens the Neurovascular Unit and Inhibits Retinal Vascular Regression Under Hyperoxic ConditionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.