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Article

Detection of H2O2-mediated phosphorylation of kinase-inactive PDGFRα.

Methods in enzymology - 1 Jan 2013

Lei Hetian, Kazlauskas Andrius

Abstract excerpt

Platelet-derived growth factor (PDGF) receptor α (PDGFRα) belongs to the 58-member family of receptor tyrosine kinases and contributes to a variety of physiological and pathological settings. Activation of PDGFRα proceeds by at least two mechanisms. The traditional route involves PDGF-dependent dimerization and activation of the receptor's intrinsic kinase activity. The second mechanism proceeds intracellularly...

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PMID: 23849866
DOI: 10.1016/B978-0-12-405881-1.00011-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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