Article
Platelet-derived growth factor and reactive oxygen species (ROS) regulate Ras protein levels in primary human fibroblasts via ERK1/2. Amplification of ROS and Ras in systemic sclerosis fibroblasts.
The Journal of biological chemistry - 28 Oct 2005
Svegliati Silvia, Cancello Raffaella, Sambo Paola, Luchetti Michele, Paroncini Paolo, Orlandini Guido, Discepoli Giancarlo, Paterno Roberto, Santillo Mariarosaria, Cuozzo Concetta, Cassano Silvana, Avvedimento Enrico V, Gabrielli Armando
Abstract excerpt
The levels of Ras proteins in human primary fibroblasts are regulated by PDGF (platelet-derived growth factor). PDGF induced post-transcriptionally Ha-Ras by stimulating reactive oxygen species (ROS) and ERK1/2. Activation of ERK1/2 and high ROS levels stabilize Ha-Ras protein, by inhibiting proteasomal degradation. We found a remarkable example in vivo of amplification of this circuitry in fibroblasts derived...
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