Article
Differences in the regulation of K-Ras and H-Ras isoforms by monoubiquitination.
The Journal of biological chemistry - 27 Dec 2013
Baker Rachael, Wilkerson Emily M, Sumita Kazutaka, Isom Daniel G, Sasaki Atsuo T, Dohlman Henrik G, Campbell Sharon L
Abstract excerpt
Ras GTPases are signaling switches that control critical cellular processes including gene expression, differentiation, and apoptosis. The major Ras isoforms (K, H, and N) contain a conserved core GTPase domain, but have distinct biological functions. Among the three Ras isoforms there are clear differences in post-translational regulation, which contribute to differences in localization and signaling output....
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