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Article

TFEB-driven endocytosis coordinates MTORC1 signaling and autophagy

27 Aug 2018

Abstract excerpt

The mechanistic target of rapamycin kinase complex 1 (MTORC1) is a central cellular kinase that integrates major signaling pathways, allowing for regulation of anabolic and catabolic processes including macroautophagy/autophagy and lysosomal biogenesis. Essential to these processes is the regulatory activity of TFEB (transcription factor EB). In a regulatory feedback loop modulating transcriptional levels of...

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Share to Autophagy in Disease and Therapy
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PMID: 30145926
DOI: 10.1080/15548627.2018.1511504

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