Article
Mutation at the cargo-receptor binding site of Atg8 also affects its general autophagy regulation function.
Autophagy - 1 May 2009
Ho Kung-Hsien, Chang Hsiang-En, Huang Wei-Pang
Abstract excerpt
Autophagy is a highly conserved degradation pathway for intracellular macromolecules and organelles. Among those characterized autophagy regulators, the ubiquitin-like protein Atg8 is found to be a membrane modifier that both regulates biogenesis of transport vesicles and interacts with the cargo receptor Atg19 for selective autophagic transport of the vacuolar enzyme prApe1 in budding yeast. The role of Atg8 in...
Topics
- Amino Acid Sequence
- Amino Acid Substitution
- Aminopeptidases
- Autophagy
- Autophagy-Related Protein 8 Family
- Autophagy-Related Proteins
- Binding Sites
- Microtubule-Associated Proteins
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Protein Binding
- Protein Transport
- Receptors, Cell Surface
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Sequence Alignment
- Vesicular Transport Proteins