In Vivo Detection of Succinate by Magnetic Resonance Spectroscopy as a Hallmark of SDHx Mutations in Paraganglioma.

doi:10.1158/1078-0432.CCR-15-1576

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Article

In Vivo Detection of Succinate by Magnetic Resonance Spectroscopy as a Hallmark of SDHx Mutations in Paraganglioma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2016

Lussey-Lepoutre Charlotte, Bellucci Alexandre, Morin Aurélie, Buffet Alexandre, Amar Laurence, Janin Maxime, Ottolenghi Chris, Zinzindohoué Franck, Autret Gwennhael, Burnichon Nelly, Robidel Estelle, Banting Benjamin, Fontaine Sébastien, Cuenod Charles-André, Benit Paule, Rustin Pierre, Halimi Philippe, Fournier Laure, Gimenez-Roqueplo Anne-Paule, Favier Judith, Tavitian Bertrand

Abstract excerpt

PURPOSE: Germline mutations in genes encoding mitochondrial succinate dehydrogenase (SDH) are found in patients with paragangliomas, pheochromocytomas, gastrointestinal stromal tumors, and renal cancers. SDH inactivation leads to a massive accumulation of succinate, acting as an oncometabolite and which levels, assessed on surgically resected tissue are a highly specific biomarker of SDHx-mutated tumors. The aim...

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Identifiers

PMID: 26490314
DOI: 10.1158/1078-0432.CCR-15-1576

Genes

SDHA
SDHB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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In Vivo Detection of Succinate by Magnetic Resonance Spectroscopy as a Hallmark of SDHx Mutations in Paraganglioma.PMID 26490314Read ↗

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