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Article

Succinate: A Serum Biomarker of SDHB-Mutated Paragangliomas and Pheochromocytomas.

The Journal of clinical endocrinology and metabolism - 28 Sept 2022

Lamy Constance, Tissot Hubert, Faron Matthieu, Baudin Eric, Lamartina Livia, Pradon Caroline, Al Ghuzlan Abir, Leboulleux Sophie, Perfettini Jean-Luc, Paci Angelo, Hadoux Julien, Broutin Sophie

Abstract excerpt

CONTEXT: Pheochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumors that are frequently associated with succinate dehydrogenase (SDH) germline mutations. When mutated, SDH losses its function, thus leading to succinate accumulation. OBJECTIVE: In this study, we evaluated serum succinate levels as a new metabolic biomarker in SDHx-related carriers. METHODS: Retrospective monocentric study of 88...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35948272
DOI: 10.1210/clinem/dgac474

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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Succinate: A Serum Biomarker of SDHB-Mutated Paragangliomas and Pheochromocytomas.PMID 35948272Read ↗

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In Vivo Detection of Succinate by Magnetic Resonance Spectroscopy as a Hallmark of SDHx Mutations in Paraganglioma.Semantic proximity Read ↗

Succinate Mediates Tumorigenic Effects via Succinate Receptor 1: Potential for New Targeted Treatment Strategies in Succinate Dehydrogenase Deficient Paragangliomas.Semantic proximity Read ↗

Clinical Practice Guidance: Surveillance for phaeochromocytoma and paraganglioma in paediatric succinate dehydrogenase gene mutation carriersSemantic proximity Read ↗

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