Article
Metabolome profiling by HRMAS NMR spectroscopy of pheochromocytomas and paragangliomas detects SDH deficiency: clinical and pathophysiological implications.
Neoplasia (New York, N.Y.) - 1 Jan 2015
Imperiale Alessio, Moussallieh François-Marie, Roche Philippe, Battini Stéphanie, Cicek A Ercument, Sebag Frédéric, Brunaud Laurent, Barlier Anne, Elbayed Karim, Loundou Anderson, Bachellier Philippe, Goichot Bernard, Stratakis Constantine A, Pacak Karel, Namer Izzie-Jacques, Taïeb David
Abstract excerpt
Succinate dehydrogenase gene (SDHx) mutations increase susceptibility to develop pheochromocytomas/paragangliomas (PHEOs/PGLs). In the present study, we evaluate the performance and clinical applications of (1)H high-resolution magic angle spinning (HRMAS) nuclear magnetic resonance (NMR) spectroscopy-based global metabolomic profiling in a large series of PHEOs/PGLs of different genetic backgrounds. Eighty-seven...
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