Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Skewed X chromosome inactivation and female preponderance in autoimmune thyroid disease: an association study and meta-analysis.

The Journal of clinical endocrinology and metabolism - 1 Jan 2014

Simmonds Matthew J, Kavvoura Fotini K, Brand Oliver J, Newby Paul R, Jackson Laura E, Hargreaves Chantal E, Franklyn Jayne A, Gough Stephen C L

Abstract excerpt

CONTEXT: A number of small data sets have suggested a potential role for skewed X chromosome activation (XCI), away from the expected 50:50 parent of origin ratio, as an explanation for the strong female preponderance seen in the common autoimmune thyroid diseases (AITD), Graves' disease (GD), and Hashimoto's thyroiditis (HT). OBJECTIVE: The objective of the study was to confirm a role for XCI skewing as a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Association Studies
Share to Pedigree

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Sex Factors

Share to Thyroiditis, Autoimmune

Share to United Kingdom

Share to White People

Share to X Chromosome Inactivation

Share to Young Adult

Source

Identifiers

PMID: 24187400
DOI: 10.1210/jc.2013-2667

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Skewed X chromosome inactivation and female preponderance in autoimmune thyroid disease: an association study and meta-analysis.PMID 24187400Read ↗

High frequency of skewed X-chromosome inactivation in females with autoimmune thyroid disease: a possible explanation for the female predisposition to thyroid autoimmunity.Semantic proximity Read ↗

Skewed X chromosome inactivation in girls and female adolescents with autoimmune thyroid diseaseSemantic proximity Read ↗

Evidence from autoimmune thyroiditis of skewed X-chromosome inactivation in female predisposition to autoimmunity.Semantic proximity Read ↗

Analysis of skewed X-chromosome inactivation in females with rheumatoid arthritis and autoimmune thyroid diseases.Semantic proximity Read ↗

Escape from X chromosome inactivation and female bias of autoimmune diseases.Semantic proximity Read ↗

Skewing of X chromosome inactivation in autoimmunity.Semantic proximity Read ↗

Preferential X Chromosome Inactivation as a Mechanism to Explain Female Preponderance in Myasthenia GravisSemantic proximity Read ↗

The X chromosome and the sex ratio of autoimmunity.Semantic proximity Read ↗

Escape from X Chromosome Inactivation and the Female Predominance in Autoimmune Diseases.Semantic proximity Read ↗

Evaluation of the X-chromosome inactivation patterns in females with Gabriele-de Vries syndrome and expansion of clinical spectrumSemantic proximity Read ↗

Diminished sex hormone levels influence the risk of skewed X chromosome inactivationSemantic proximity Read ↗

The X chromosome in female-predominant autoimmune diseases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.