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Article

Evidence from autoimmune thyroiditis of skewed X-chromosome inactivation in female predisposition to autoimmunity.

European journal of human genetics : EJHG - 1 Jun 2006

Ozcelik Tayfun, Uz Elif, Akyerli Cemaliye B, Bagislar Sevgi, Mustafa Chigdem A, Gursoy Alptekin, Akarsu Nurten, Toruner Gokce, Kamel Nuri, Gullu Sevim

Abstract excerpt

The etiologic factors in the development of autoimmune thyroid diseases (AITDs) are not fully understood. We investigated the role of skewed X-chromosome inactivation (XCI) mosaicism in female predisposition to AITDs. One hundred and ten female AITDs patients (81 Hashimoto's thyroiditis (HT), 29 Graves' disease (GD)), and 160 female controls were analyzed for the androgen receptor locus by the HpaII/polymerase...

Topics

Adult
Chromosomes, Human, X
Female
Genetic Predisposition to Disease
Graves Disease
Hashimoto Disease
Humans
Male
Middle Aged
Mosaicism
Pedigree

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sex Factors

X Chromosome Inactivation

Source

Identifiers

PMID: 16596118
DOI: 10.1038/sj.ejhg.5201614

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