Article
A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice.
eLife - 20 Apr 2021
Petr Michael A, Alfaras Irene, Krawcyzk Melissa, Bair Woei-Nan, Mitchell Sarah J, Morrell Christopher H, Studenski Stephanie A, Price Nathan L, Fishbein Kenneth W, Spencer Richard G, Scheibye-Knudsen Morten, Lakatta Edward G, Ferrucci Luigi, Aon Miguel A, Bernier Michel, de Cabo Rafael
Abstract excerpt
Aging is associated with distinct phenotypical, physiological, and functional changes, leading to disease and death. The progression of aging-related traits varies widely among individuals, influenced by their environment, lifestyle, and genetics. In this study, we conducted physiologic and functional tests cross-sectionally throughout the entire lifespan of male C57BL/6N mice. In parallel, metabolomics analyses...
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