Article
A functional analysis of mouse models of cardiac disease through metabolic profiling.
The Journal of biological chemistry - 4 Mar 2005
Jones Gareth L A H, Sang Elizabeth, Goddard Catharine, Mortishire-Smith Russell J, Sweatman Brian C, Haselden John N, Davies Kay, Grace Andrew A, Clarke Kieran, Griffin Julian L
Abstract excerpt
Since the completion of the human and mouse genomes, the focus in mammalian biology has been on assessing gene function. Tools are needed for assessing the phenotypes of the many mouse models that are now being generated, where genes have been "knocked out," "knocked in," or mutated, so that gene expression can be understood in its biological context. Metabolic profiling of cardiac tissue through high resolution...
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