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Article

ESET methylates UBF at K232/254 and regulates nucleolar heterochromatin plasticity and rDNA transcription.

Nucleic acids research - 1 Feb 2014

Hwang Yu Jin, Han Dohyun, Kim Ki Yoon, Min Sun-Joon, Kowall Neil W, Yang Liu, Lee Junghee, Kim Youngsoo, Ryu Hoon

Abstract excerpt

The remodeling of chromatin in the nucleolus is important for the control of ribosomal DNA (rDNA) transcription and ribosome biogenesis. Herein, we found that upstream binding factor (UBF) interacts with ESET, a histone H3K9 methyltransferase and is trimethylated at Lys (K) 232/254 by ESET. UBF trimethylation leads to nucleolar chromatin condensation and decreased rDNA transcriptional activity. UBF mutations at...

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Identifiers

PMID: 24234436
DOI: 10.1093/nar/gkt1041
PMCID: PMC3919562

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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