Article
Dysregulation of upstream binding factor-1 acetylation at K352 is linked to impaired ribosomal DNA transcription in Huntington's disease.
Cell death and differentiation - 1 Nov 2011
Lee J, Hwang Y J, Boo J H, Han D, Kwon O K, Todorova K, Kowall N W, Kim Y, Ryu H
Abstract excerpt
Huntington's disease (HD) is an autosomal-dominant neurological disorder caused by expanded CAG repeats in the Huntingtin (Htt) gene, but it is not known how this mutation causes neurodegeneration. Herein, we found that dysfunction of upstream binding factor-1 (UBF-1) is linked to reduced ribosomal DNA (rDNA) transcription in HD. We identified that UBF1 acetylation at Lys (K) 352 by CREB binding protein (CBP) is...
Topics
- Acetylation
- Animals
- CREB-Binding Protein
- Cell Line
- Chromatin Immunoprecipitation
- DNA, Ribosomal
- Disease Models, Animal
- Huntington Disease
- Lysine
- Male
- Mice