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Article

Recent advances in understanding the pathogenesis of Huntington's disease.

Trends in neurosciences - 1 Jun 1999

Reddy P H, Williams M, Tagle D A

Abstract excerpt

Huntington's disease (HD) is an autosomal, dominantly inherited neurodegenerative disorder that is characterized by abnormal involuntary movements (chorea), intellectual impairment and selective neuronal loss. The expansion of a polymorphic trinucleotide repeat (the sequence CAG that codes for glutamine) to a length that exceeds 40 repeat units in exon 1 of the gene, HD, correlates with the onset and progression...

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PMID: 10354600
DOI: 10.1016/s0166-2236(99)01415-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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