Article
Downregulation of L-type Ca2+ channel in rat mesenteric arteries leads to loss of smooth muscle contractile phenotype and inward hypertrophic remodeling.
American journal of physiology. Heart and circulatory physiology - 1 May 2014
Kudryavtseva Olga, Herum Kate Møller, Dam Vibeke Secher, Straarup Marthe Simonsen, Kamaev Dmitry, Briggs Boedtkjer Donna M, Matchkov Vladimir V, Aalkjær Christian
Abstract excerpt
L-type Ca(2+) channels (LTCCs) are important for vascular smooth muscle cell (VSMC) contraction, as well as VSMC differentiation, as indicated by loss of LTCCs during VSMC dedifferentiation. However, it is not clear whether loss of LTCCs is a primary event underlying phenotypic modulation or whether loss of LTCCs has significance for vascular structure. We used small interference RNA (siRNA) transfection in vivo...
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