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Article

A functional single-nucleotide polymorphism in the human cytidine deaminase gene contributing to ara-C sensitivity.

Pharmacogenetics - 1 Jan 2003

Yue Lijie, Saikawa Yutaka, Ota Kazuhisa, Tanaka Motohiro, Nishimura Ryosei, Uehara Takahiro, Maeba Hideaki, Ito Takashi, Sasaki Takuma, Koizumi Shoichi

Abstract excerpt

To test the hypothesis that analyses of drug targets for polymorphism will help to establish gene-based information for the treatment of cancer patients, we investigated the functional single-nucleotide polymorphisms in the human cytidine deaminase (HDCA) gene. The cDNAs from 52 leukaemia/lymphoma samples and 169 control blood samples were direct-sequenced and analysed for the polymorphisms. Three different...

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Identifiers

PMID: 12544510
DOI: 10.1097/00008571-200301000-00005

Genes

CDA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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