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Article

The Pygo2-H3K4me2/3 interaction is dispensable for mouse development and Wnt signaling-dependent transcription.

Development (Cambridge, England) - 1 Jun 2013

Cantù Claudio, Valenta Tomas, Hausmann George, Vilain Nathalie, Aguet Michel, Basler Konrad

Abstract excerpt

Pygopus has been discovered as a fundamental Wnt signaling component in Drosophila. The mouse genome encodes two Pygopus homologs, Pygo1 and Pygo2. They serve as context-dependent β-catenin coactivators, with Pygo2 playing the more important role. All Pygo proteins share a highly conserved plant homology domain (PHD) that allows them to bind di- and trimethylated lysine 4 of histone H3 (H3K4me2/3). Despite the...

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Chromatin Assembly and Disassembly
Fertility
Gene Knock-In Techniques
Histones
p300-CBP Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Interaction Domains and Motifs

Wnt Signaling Pathway

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PMID: 23637336
DOI: 10.1242/dev.093591

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