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Article

Pygo-F773W Mutation Reveals Novel Functions beyond Wnt Signaling in Drosophila.

International journal of molecular sciences - 30 May 2024

Li Youfeng, Jiang Zhigang, Xu Yue, Yan Jing, Wu Qiong, Huang Sirui, Wang Lingxiao, Xie Yulian, Wu Xiushan, Wang Yuequn, Li Yongqing, Fan Xiongwei, Li Fang, Yuan Wuzhou

Abstract excerpt

Pygopus (Pygo) has been identified as a specific nuclear co-activator of the canonical Wingless (Wg)/Wnt signaling pathway in Drosophila melanogaster. Pygo proteins consist of two conserved domains: an N-terminal homologous domain (NHD) and a C-terminal plant homologous domain (PHD). The PHD's ability to bind to di- and trimethylated lysine 4 of histone H3 (H3K4me2/3) appears to be independent of Wnt signaling....

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Identifiers

PMID: 38892188
DOI: 10.3390/ijms25115998
PMCID: PMC11172468

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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