Article

Antagonistic roles of canonical and alternative RPA in tandem CAG repeat diseases

2022-10-26

Abstract excerpt

<h4>ABSTRACT</h4> Tandem CAG repeat expansion mutations cause >15 neurodegenerative diseases, where ongoing expansions in patients’ brains are thought to drive disease onset and progression. Repeat length mutations will involve single-stranded DNAs prone to form mutagenic DNA structures. However, the involvement of single-stranded DNA binding proteins (SSBs) in the prevention or formation of repeat instability is...

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Literature Corpus work: 2e0633ef-4bce-56b4-9438-84aab9778ebf
DOI: 10.1101/2022.10.24.513561

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