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Article

Large T Antigens of Polyomaviruses: Amazing Molecular Machines

20 Sept 2012

Abstract excerpt

The large tumor antigen (T antigen) encoded by simian virus 40 is an amazing molecular machine because it orchestrates viral infection by modulating multiple fundamental viral and cellular processes. T antigen is required for viral DNA replication, transcription, and virion assembly. In addition, T antigen targets multiple cellular pathways, including those that regulate cell proliferation, cell death, and the...

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PMID: 22994493
DOI: 10.1146/annurev-micro-092611-150154

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