Article
Simian virus 40 regulatory region structural diversity and the association of viral archetypal regulatory regions with human brain tumors.
Seminars in cancer biology - 1 Feb 2001
Lednicky J A, Butel J S
Abstract excerpt
The regulatory region (RR) of simian virus 40 (SV40) contains enhancer/promoter elements and an origin of DNA replication. Natural SV40 isolates from simian brain or kidney tissues typically have an archetypal RR arrangement with a single 72-basepair enhancer element. A rare simpler, shorter SV40 RR exists that lacks a duplicated sequence in the G/C-rich region and is termed protoarchetypal. Occasionally, SV40...
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