Simian virus 40 regulatory region structural diversity and the association of viral archetypal regulatory regions with human brain tumors.

doi:10.1006/scbi.2000.0345

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Article

Simian virus 40 regulatory region structural diversity and the association of viral archetypal regulatory regions with human brain tumors.

Seminars in cancer biology - 1 Feb 2001

Lednicky J A, Butel J S

Abstract excerpt

The regulatory region (RR) of simian virus 40 (SV40) contains enhancer/promoter elements and an origin of DNA replication. Natural SV40 isolates from simian brain or kidney tissues typically have an archetypal RR arrangement with a single 72-basepair enhancer element. A rare simpler, shorter SV40 RR exists that lacks a duplicated sequence in the G/C-rich region and is termed protoarchetypal. Occasionally, SV40...

Topics

Animals
Antigens, Polyomavirus Transforming
Binding Sites
Brain Neoplasms
DNA, Viral
Genetic Variation
Humans
Regulatory Sequences, Nucleic Acid
Simian virus 40

Source

Open in PubMed

Identifiers

PMID: 11243898
DOI: 10.1006/scbi.2000.0345

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