Article
Natural isolates of simian virus 40 from immunocompromised monkeys display extensive genetic heterogeneity: new implications for polyomavirus disease.
Journal of virology - 1 May 1998
Lednicky J A, Arrington A S, Stewart A R, Dai X M, Wong C, Jafar S, Murphey-Corb M, Butel J S
Abstract excerpt
Simian virus 40 (SV40) DNAs in brain tissue and peripheral blood mononuclear cells (PBMCs) of eight simian immunodeficiency virus-infected rhesus monkeys with SV40 brain disease were analyzed. We report the detection, cloning, and identification of five new SV40 strains following a quadruple testing-verification strategy. SV40 genomes with archetypal regulatory regions (containing a duplication within the...
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