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Article

Deactivation blocks proton pathways in the mitochondrial complex I.

Proceedings of the National Academy of Sciences of the United States of America - 20 Jul 2021

Röpke Michael, Riepl Daniel, Saura Patricia, Di Luca Andrea, Mühlbauer Max E, Jussupow Alexander, Gamiz-Hernandez Ana P, Kaila Ville R I

Abstract excerpt

Cellular respiration is powered by membrane-bound redox enzymes that convert chemical energy into an electrochemical proton gradient and drive the energy metabolism. By combining large-scale classical and quantum mechanical simulations with cryo-electron microscopy data, we resolve here molecular details of conformational changes linked to proton pumping in the mammalian complex I. Our data suggest that complex I...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34272275
DOI: 10.1073/pnas.2019498118
PMCID: PMC8307655

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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