Article
Mapping hydration dynamics around a protein surface.
Proceedings of the National Academy of Sciences of the United States of America - 20 Nov 2007
Zhang Luyuan, Wang Lijuan, Kao Ya-Ting, Qiu Weihong, Yang Yi, Okobiah Oghaghare, Zhong Dongping
Abstract excerpt
Protein surface hydration is fundamental to its structure and activity. We report here the direct mapping of global hydration dynamics around a protein in its native and molten globular states, using a tryptophan scan by site-specific mutations. With 16 tryptophan mutants and in 29 different positions and states, we observed two robust, distinct water dynamics in the hydration layer on a few ( approximately 1-8...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.